Peer-reviewed Journal Articles and Book Chapters (students and postdocs in boldface)

  1. J.F. LaDisa, Jr., C.E. Larkee. The MARquette Visualization Lab (MARVL): an immersive virtual environment for research, teaching and collaboration. Front. Educ., April 2020 Volume 5 Article 38 pdf
  2. J.F. LaDisa, Jr., A. Tomita-Mitchell, K. Stamm, K. Bazan, D.K. Mahnke, M. Goetsch, B.J. Wegter, J.W. Gerringer, K. Repp, O. Palygin, A.P. Zietara, M.M. Krolikowski, T.J. Eddinger, A.A. Alli, M.E. Mitchell. Human genotyping and a experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta. Physiol Genomics. 2019 Jun 1;51(6):177-185 pdf
  3. A. Ghorbanniahassankiadeh, D.S. Marks, J.F. LaDisa, Jr. A computational study assessing threshold criteria for the treatment of left main coronary artery bifurcations containing multiple stenoses. In press - To Appear in Biomedical Sciences Instrumentation 
  4. A. Razavi, S. Sachdeva, P.C. Frommelt, J.F. LaDisa, Jr. Selection of patient-specific boundary conditions with application to anomalous aortic origin of a coronary artery under resting and stress conditions. In press - To Appear in Biomedical Sciences Instrumentation
  5. H.S. Kandail, S.D. Trivedi, A.C. Shaikh, T.K. Bajwa, D.P. O’Hair, A. Jahangir, J.F. LaDisa, Jr. Impact of annular and supra-annular CoreValve deployment locations on aortic and coronary artery hemodynamics. J Mech Behav Biomed Mater. 2018 Oct; 86:131-142. pdf
  6. D.C. Wendell, I. Friehs, M.M. Samyn, L.M Harmann, J.F. LaDisa, Jr. Treating a 20 mm Hg gradient alleviates myocardial hypertrophy in experimental aortic coarctation. J Surg Res. 2017 Oct;218:194-201. pdf
  7. M.M. Samyn, J.F. LaDisa, Jr. Novel Applications of Cardiovascular Magnetic Resonance Imaging-Based Computational Fluid Dynamics Modeling in Pediatric Cardiovascular and Congenital Heart Disease. In Magentic Resonance Imaging. 2016 Editor: Christakis Constantinides, InTech  pdf
  8. L. Ellwein, M.M. Samyn, M. Danduran, S. Schindler-Ivens, S. Liebham, J.F. LaDisa, Jr. Toward translating near-infrared spectroscopy oxygen saturation data for the non-invasive prediction of spatial and temporal hemodynamics during exercise. Biomech Model Mechanobiol. 2016 Jul 4. doi: 10.1007/s10237-016-0803-4. [Epub ahead of print]​ pdf  data 
  9. D.C. Wendell, M.M. Samyn, J.R. Cava, M.M. Krolikowski, J.F. LaDisa, Jr. The impact of cardiac motion on aortic valve flow used in computational simulations of the thoracic aorta. J Biomech Eng. 2016 Sep 1;138(9). doi: 10.1115/1.4033964. pdf
  10. C. Chiastra, W. Wu, B. Dickerhoff, A. Aleiou, H. Otake, F. Migliavacca, J.F. LaDisa, Jr. Computational replication of the patient-specific stenting procedure for coronary artery bifurcations: from OCT and CT imaging to structural and hemodynamics analyses. J Biomech. 2015 Nov 27. pii: S0021-9290(15)00666-1. doi: 10.1016/j.jbiomech.2015.11.024. pdf
  11. L. Ellwein, D.S. Marks, R.Q. Migrino, W.D. Foley, S. Sherman, J.F. LaDisa, Jr. Image-based quantification of 3-D morphology for bifurcations in the left coronary artery: application to stent design. Catheter Cardiovasc Interv. 2016 Jun;87(7):1244-55 pdf
  12. H. Wang, J.R. Kersten, J.M. Toth, D. Weihrauch, S. Schrepfer, J.F. LaDisa, Jr. Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40. pdf
  13. J.F. LaDisa, Jr., S. Bozdag, J. Olson, R. Ramchandran, J.R. Kersten, T.J. Eddinger. Gene expression in experimental aortic coarctation and repair: candidate genes for therapeutic intervention? PLoS One. 2015 Jul 24;10(7):e0133356. pdf
  14. M.M. Samyn, R.J. Dholakia, H. Wang, J. Co-Vu, K. Yan, M.E. Widlansky, J.F. LaDisa, Jr., P. Simpson, R. Alemzadeh. Cardiovascular magnetic resonance imaging-based computational fluid dynamics/fluid-structure interaction pilot study to detect early vascular changes in pediatric patients with type 1 diabetes. Pediatr Cardiol. 2015 Apr;36(4):851-61. pdf
  15. D.J. Quam, T.J. Gundert, L.M. Ellwein, C.E. Larkee, P. Hayden, R.Q. Migrino, H. Otake, J.F. LaDisa, Jr. Immersive visualization for enhanced computational fluids dynamics analysis. J Biomech Eng. 2015 Mar 1;137(3). pdf
  16. S. Kwon, J.A. Feinstein, R.J. Dholakia, J.F. LaDisa, Jr. Quantification of local hemodynamic alterations caused by virtual implantation of three commercially-available stents for the treatment of aortic coarctation. Pediatr Cardiol. 2014 Apr;35(4):732-40. pdf
  17. T.J. Gundert, R.J. Dholakia, D. McMahon, J.F. LaDisa, Jr. Computational fluid dynamics evaluation of equivalency in hemodynamic alterations between Driver, Integrity and similar stents implanted into an idealized coronary artery. J Med Device. 2013 Mar;7:011004 doi:10.1115/1.4023413 pdf
  18. A. Menon, T.J. Eddinger, H. Wang, D.C. Wendell, J.M. Toth, J.F. LaDisa, Jr. Altered hemodynamics, endothelial function and protein expression occur with aortic coarctation and persist following repair. Am J Physiol Heart Circ Physiol. 2012 Dec;303(11):H1304-18. pdf
  19. D.C. Wendell, M.M. Samyn, J.R. Cava, L.M. Ellwein, M.M. Krolikowski, K.L. Gandy, A.N. Pelech, S.C. Shadden, J.F. LaDisa, Jr. Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. Med Eng Phys. 2012 Aug 20. [Epub ahead of print] DOI:10.1016/j.medengphy.2012.07.015 pdf
  20. T.J. Gundert, A.L. Marsden, W. Yang, D.S. Marks, J.F. LaDisa, Jr. Identification of hemodynamically optimal coronary stent designs based on vessel diameter. IEEE Trans Biomed Eng. 2012 July; 59(7):1992-2002. pdf
  21. J.S. Coogan, F.P. Chan, J.F. LaDisa, Jr., C.A. Taylor, F.L. Hanley, J.A. Feinstein. Computational fluid dynamic simulations for determination of ventricular workload in aortic arch obstructions. J Thorac Cardiovasc Surg. 2012 Apr 17. [Epub ahead of print] pdf
  22. T.J. Gundert, A.L. Marsden, W. Yang, J.F. LaDisa, Jr. Optimization of cardiovascular stent design using computational fluid dynamics. J. Biomech. Eng. 2012 Jan;134(1):011002 doi:10.1115/1.4005542. 1 of 9 papers selected to the 2012 Editor's Choice list pdf
  23. A. Menon, D.C. Wendell, H. Wang, T.J. Eddinger, J.M. Toth, R.J. Dholakia, P.M. Larsen, E.S. Jensen, J.F. LaDisa, Jr. A novel coupled experimental and computational approach to quantify deleterious hemodynamics, vascular alterations, and mechanisms of long-term morbidity in response to aortic coarctation. J Pharmacol Toxicol Meth. 2012 Jan; 65(1):18-28. pdf
  24. J.F. LaDisa, Jr.*, C.A. Figueroa*, I.E. Vignon-Clementel,  H.J. Kim, N. Xiao, L.M. Ellwein, F.P. Chan, J.A. Feinstein, C.A. Taylor. Computational simulations for aortic coarctation: representative results from a sampling of patients. J. Biomech. Eng. 2011 Sep;133(9):091008. doi:10.1115/1.4004996. * = authors contributed equally pdf
  25. J.F. LaDisa, Jr., R.J. Dholakia, C.A. Figueroa, I.E. Vignon-Clementel, F.P. Chan, M.M. Samyn, J.R. Cava, C.A. Taylor, J.A. Feinstein. Computational simulations demonstrate altered wall shear stress in aortic coarctation patients previously treated by resection with end-to-end anastomosis. Congenit Heart Dis. 2011 Sep; 6(5): 432-43. pdf
  26. L.M. Ellwein, H. Otake, T.J. Gundert, B.K. Koo, T. Shinke, Y. Honda, J. Shite, J.F. LaDisa, Jr. Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. Cardiovasc Eng Tech. 2011 Sept; 2(3): 212-7. pdf
  27. R.Q. Migrino, M.R. Bowers, L. Harmann, R. Prost, J.F. LaDisa, Jr. Carotid plaque regression following 6-month statin therapy assessed by 3T MRI: comparison with ultrasound intima media thickness. J Cardiovasc Magn Reson. 2011 Aug 3;13(1):37. pdf
  28. T.J. Gundert, S.C. Shadden, A.R. Williams, B.K. Koo, J.A. Feinstein, J.F. LaDisa, Jr. A rapid and computationally inexpensive method for assessing patient-specific hemodynamic alterations introduced by commercially available and next-generation stents. Ann Biomed Eng. 2011 May; 39(5): 1423-37. pdf
  29. J.F. LaDisa, Jr., C.A. Taylor, J.A. Feinstein. Aortic coarctation: recent developments in experimental and computational methods to assess treatments for this simple condition. Prog Pediatr Cardiol 2010 Dec; 30(1): 45-9. pdf
  30. A.R. Williams, B.K. Koo, T.J. Gundert, P.J. Fitzgerald, J.F. LaDisa, Jr. Local hemodynamic changes caused by main branch stent implantation and subsequent side branch balloon angioplasty in a representative coronary bifurcation. J Appl Physiol. 2010 Aug; 109(2): 532-40. pdf
  31. J.E. Moore Jr., L.H. Timmins, J.F. LaDisa, Jr. Coronary artery bifurcation biomechanics and implications for interventional strategies. Catheter Cardiovasc Interv. 2010 Nov 15; 76(6):836-43. pdf
  32. J.F. LaDisa, Jr., M.R. Bowers, L. Harmann, R. Prost, A. Doppalapudi, T. Mohyuddin, O. Zaidat, R.Q. Migrino. Time-efficient patient-specific quantification of regional carotid artery fluid dynamics and spatial correlation with plaque burden following statin treatment. Medical Physics. 2010 Feb; 37(2): 784-92. pdf
  33. H.J. Kim, I.E. Vignon-Clementel, C.A. Figueroa, J.F. LaDisa, Jr, K.E. Jansen, J.A. Feinstein, C.A. Taylor. On coupling a lumped parameter heart model and a three-dimensional finite element aorta model. Ann Biomed Eng. 2009 Nov; 37(11): 2153-69. pdf
  34. J.F. LaDisa, Jr., C.A. Taylor, J.A. Feinstein. Endovascular treatment strategies for coarctation of the aorta. In: Current Treatment of Thoracic Aortic Diseases. 2006. Editor: Herve Rousseau, Springer, pp. 363-374. pdf
  35. J.F. LaDisa, Jr., L.E. Olson, D.A. Hettrick, D.C. Warltier, J.R. Kersten, P.S. Pagel. Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling. Biomed Eng Online. 2006 June 16; 5:40. pdf
  36. J.F. LaDisa, Jr., L.E. Olson, D.A. Hettrick, D.C. Warltier, J.R. Kersten, P.S. Pagel. Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening. Biomed Eng Online. 2005 Oct 26; 4(1):59. pdf
  37. J.F. LaDisa, Jr., L.E. Olson, K.M. Ropella, R.C. Molthen, S.T. Haworth, J.R. Kersten, D.C. Warltier, P.S. Pagel. Microfocal x-ray computed tomography post-processing operations for optimizing reconstruction volumes of stented arteries during 3D computational fluid dynamics modeling. Comput Methods Programs Biomed. 2005 Aug; 79(2):121-34. pdf
  38. J.F. LaDisa, Jr., L.E. Olson, R.C. Molthen, D.A. Hettrick, M.D. Hardel, P.F. Pratt, J.R. Kersten, D.C. Warltier, P.S. Pagel. Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2465-75. pdf
  39. J.F. LaDisa, Jr., L.E. Olson, I. Guler, D.A. Hettrick, J.R. Kersten, D.C. Warltier, P.S. Pagel. Circumferential vascular deformation after stent implantation alters wall shear stress evaluated using time-dependent 3D computational fluid dynamics models. J Appl Physiol. 2005; 98(3):947-57. pdf
  40. J.F. LaDisa, Jr., H.T. Meier, L.E. Olson, J.R. Kersten, D.C. Warltier, P.S. Pagel. Antegrade iliac artery stent implantation for the temporal and spatial examination of stent-induced neointimal hyperplasia and alterations in regional fluid dynamics. J Pharmacol Toxicol Methods. 2005 Mar-Apr; 51(2):115-21. pdf
  41. John F. LaDisa Jr., John G. Krolikowski, Paul S. Pagel, David C. Warltier, Judy R. Kersten. Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2): H601-7. pdf
  42. J.F. LaDisa, Jr., L.E. Olson, I. Guler, D.A. Hettrick, S.H. Audi, J.R. Kersten, D.C. Warltier, P.S. Pagel. Stent design properties and deployment ratio influence indices of wall shear stress: a 3D computational fluid dynamics investigation within a normal artery. J Appl Physiol. 2004 July; 97(1):424-30. pdf     Related Commentary     Related editorial
  43. F. Kehl, J.F. LaDisa Jr., D.A. Hettrick, J.R. Kersten, D.C. Warltier, P.S. Pagel.  Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: Evaluation with pressure-volume relationships. J of Cardiothorac and Vasc Anesth. 2003 Dec; 17(6):709-14. pdf 
  44. L.M. Ludwig, J.R. Kersten, K. Tanaka, W. Gu, J.F. LaDisa, Jr., D.C. Warltier, P.S. Pagel.  Mechanisms of volatile anesthetic-induced myocardial protection. Curr Top in Pharmacol. 2003; 7(2): 195-207. pdf
  45. J.F. LaDisa Jr., I. Guler, L.E. Olson, D.A. Hettrick, J.R. Kersten, D.C. Warltier, P.S. Pagel.  Three-dimensional computational fluid dynamics modeling of alterations in coronary artery wall shear stress produced by stent implantation. Ann Biomed Eng. 2003 Aug; 31(8):972-80. pdf
  46. J.F. LaDisa, Jr., E.R. Gross, D. Weihrauch, D.A. Hettrick, L.E. Olson, T. Kress, P.S. Pagel, D.C. Warltier, J.R. Kersten.  Reactive oxygen species modulate alterations in coronary wall shear stress and endothelial function during hyperglycemia. Am J Physiol Heart Circ Physiol. 2003 May; 284(5):H1552-9. pdf
  47. F. Kehl, J.G. Krolikowski, J.F. LaDisa Jr., J.R. Kersten, D.C. Warltier, P.S. Pagel.  Adenosine type 1 (A(1)) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs. Int J Cardiol. 2003 Apr; 88(2-3):175-82. pdf
  48. J.F. LaDisa Jr., D.A. Hettrick, L.E. Olson, I. Guler, E.R. Gross, T. Kress, J.R. Kersten, D.C. Warltier, P.S. Pagel. Stent implantation alters coronary artery hemodynamics and wall shear stress during maximal vasodilation. J Appl Physiol. 2002 Dec; 93(6):1939-46. pdf
  49. K. Tanaka, D. Weihrauch, F. Kehl, L.M. Ludwig, J.F. LaDisa Jr., J.R. Kersten, P.S. Pagel, D.C. Warltier. Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. Anesthesiology. 2002 Dec; 97(6):1485-90. pdf
  50. R. Rys, J.F. LaDisa, Jr., J.P. Tessmer, J.R. Kersten, D.C. Warltier, P.S. Pagel.  An automated coronary artery occlusion device for stimulating collateral development in vivo. J Pharmacol Toxicol Methods. 2002; 48:111-18. pdf